New Scientific Brake Trough Against Colon Cancer
A team of scientists has a gene that, if it works any more, does the incidence of colorectal cancer in the notice that there are sporadic inherited (). This discovery is expected to create new therapies and new ways of preventing colon cancer. The researchers found that this particular gene can be reactivated by a particular drug, making the vulnerability of the cancer. This research confirms that this gene, calledhMLH1, has a great importance in the fight against cancer.
Scientists know that when gene is not working properly, it will come to develop a type of colon cancer in people who have found no cases in their family. But if it works properly, it stops the DNA from the cells of damaged forever. He does so by an enzyme that detects errors in the fixation of DNA before the cell is damaged.
If the gene is disabled, theDNA methylation is loaded with a substance which the cell reproduce itself chaotically producing faulty cells makes. It is a drug known as 5-azacytide that separates the methylation of DNA and repair the cell. But scientists can use this drug and it already for a new, because a 5-is azacytide very toxic. This fact was discovered by the analysis of several patients with colon cancer. In any of these colon cancer starts during the age of 50 or 60, onlythe average time for this type of cancer.
It is proven that the hMLH1 gene is inactive in patients with colorectal cancer and it is already known how to enable and get it to work properly. After activation of this gene are more susceptible to chemotherapy patients, in this way increases the chances of the destruction of the colon tumors have them.
It can prevent the possibility of developing cancer if the DNA of the cell can be protectedOnce the gene starts off.
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